Prolotherapy and PRP (Platelet Rich Plasma) in Melbourne

Clinics located across Melbourne, Geelong and the Mornington Peninsula. Click here for locations

Prolotherapy and PRP are both natural regenerative injection therapies that are safe and effective treatments for soft tissues injuries and degeneration. They are part of the same biologics field of medicine as stem cell therapy, except they are more accessible and far less expensive.

Prolotherapy is an injection of natural glucose solution whilst PRP is an injection containing the patients’ own blood. Whilst both treatments are effective, usually prolotherapy is utilized for less severe injury or degeneration, and is much less expensive than PRP.

Please see below for a thorough explanation of each treatment.

For those patients who are needle phobic, alternative treatment options can be prescribed.


Prolotherapy is a very promising and successful medically researched treatment utilised to repair soft tissue to heal injuries involving tendons, ligaments, muscles and cartilage. This simple technique is a quick, easy, safe, fast acting and cost effective treatment used to increase strength and mobility and relieve pain.

Prolotherapy is minimally invasive natural solution of glucose and anesthetic that is injected into the damaged soft tissue causing a local inflammatory process to stimulate the body's natural healing mechanism, resulting in the deposition of new collagen to aid regeneration and assist pain.

How does it work?

Prolotherapy injections work through the proliferative action of the glucose solution. The glucose solution triggers a local inflammatory response around injured and painful tissues in order to attract the cells, which are responsible for tissue repair. These cells are recruited to the area in order to increase the laying down of collagen, the main building block in all connective tissue. With each injection, stronger and healthier tissue develops.

Because tendons, ligaments and other soft tissues generally have poor blood supply, incomplete healing often occurs after injury. Prolotherapy stimulates blood flow and new blood vessel formation, increases immune cells in the area, as well as protein synthesis, fibroblast proliferation, and ultimately collagen formation. The end result is stimulation of the immune system and repair to the damaged area. As a result there is increased joint, ligament, and tendon stability, and greater strength. Chronic joint pain is relieved and mobility increases. This is because stiffness is often due to protective muscle spasm, and once the pain from the soft tissue is relieved the muscles relax.

Other uses

Prolotherapy can also assist with muscle and nerve injuries

The technique

The solution contains between 5% and 20% glucose and a weak solution of lignocaine (local anaesthetic) is added. Sometimes stronger solutions are used for a stronger effect.

The solution is injected into the soft tissue. The local anaesthetic brings relief of pain, which can be useful diagnostically, especially if there has been some doubt where the pain is coming from. Then inflammation begins and the body’s natural healing mechanisms are initiated.

How many treatments?

The amount of injections required varies depending on the degree and location of the injury / degeneration and each individuals response to healing. Usually a series of 2 to 6 treatments are required however some patient may only require a single treatment and many patients receive relief after the first treatment, even if further treatments are required.

The spacing of treatments can vary from weeks to months, however 1 to 2 weeks apart is most common.

How effective is it?

Treatments for sports injuries are sometimes more successful because often these patients are younger, fitter and eating better. As we age we usually require more treatments and in such cases the patient may need to return in a few years for another course. The good news is, even patients in their 80’s are gaining significant benefits in reduced pain and increased capacity.

Other information

No aspirin, other anti-inflammatory drugs or liniments should be used whilst having prolotherapy, as they can reduce the healing process.
Nutrients are very important to encourage good health and repair soft tissues and may be prescribed to assist with healing. The most common are:

  • Vitamin C (makes strong connective tissue, helps healing).
  • Manganese (as chelate) - (essential for discs, cartilage).
  • Zinc (usually as chelate) - (wound healing, important for new protein).


Prolotherapy is one of the latest and most promising medically researched treatments in the regeneration and repair of soft tissues to heal injuries involving tendons, ligaments, muscles and cartilage. It’s safe, effective and non-surgical, assisting the body’s natural healing mechanisms.

Please call Foot + Leg Pain Clinics on 1300 328 300 for an appointment.


PRP – Platelet Rich Plasma

PRP Platelet-rich plasma injections are natural injections consisting of components of your own blood. A rapidly growing treatment PRP utilises the body’s natural inflammatory process to assist the growth and repair of soft tissues such as: tendons, ligaments, fascia, skin and muscle.  

PRP injections consist of blood plasma that has been enriched with platelets (also called "thrombocytes", platelets are blood cells whose function is to stop bleeding). PRP contains several different growth factors and other proteins that stimulate healing.

The goal of PRP therapy is to resolve pain and increase mobility through healing. It is completely natural and can prove to have long lasting results.

The technique

PRP preparation involves taking blood from the patients’ arm, just like a normal blood test, then undergoing centrifugation designed to separate the platelet-poor plasma and red blood cells, which are platelet-rich. The blood with the higher concentration of platelets (platelet-rich plasma) is then injected into the site of the injury. A local anaesthetic can be used so that any pain from the injection is minimal. The whole process takes about 45 minutes.

Following the procedure you may drive home however you may it appropriate to have someone with you for your journey home.

After the PRP injection

Following PRP treatment you should rest and avoid strenuous activity. Don’t expect immediate results, your body needs time to heal itself so improvement will be gradual over a number of weeks.

PRP is a clinical tool and not a stand-alone treatment option. As such, at Foot & Leg Pain Clinics we look to find the reasons why you developed the pain, injury and/or degenerative condition in the first place and put processes and preventative measures in place to minimize the possibility of re-occurrence and/or further degeneration. It’s very important to take a holistic approach to strengthen, recondition and support the body to ensure long-term health and healing.

How effective is it?

Results differ from person to person and can be dependant on the nature and severity of the injury, lifestyle choices and adherence to post therapy advice and rehabilitation services. However research studies and clinical practice have shown PRP therapy to be very effective at relieving pain and increasing function and mobility. Both ultrasound and MRI images have shown definitive tissue repair after PRP therapy.

What can be treated with PRP?

PRP can be used for several types of injuries and ailments, including:

  • Nerve injury
  • Tendinitis
  • Osteoarthritis
  • Muscle tears
  • Degenerative conditions
  • Bursitis
  • Ligament, tendon and fascia injuries

How many treatments will I need?

The number of treatments required does depend on your body’s rate healing and the particular type and severity of injury or degeneration. However, on average most people require between 2 and 6 injections. There are occasions though when a single injection is sufficient. Injections are usually 1-2 weeks apart and sometimes a single yearly injection is advised as maintenance.

Please call Foot + Leg Pain Clinics on 1300 328 300 for an appointment.

Call 1300 328 300 to feel better sooner than you think.

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